2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

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DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-130545
    3-(Pyridin-2-yldisulfanyl)propanehydrazide
    3-(Pyridin-2-yldisulfanyl)propanehydrazide is a crosslinking agent.
    3-(Pyridin-2-yldisulfanyl)propanehydrazide
  • HY-34477R
    2-Iodoacetamide (Standard)
    2-Iodoacetamide (Standard) is the analytical standard of 2-Iodoacetamide. This product is intended for research and analytical applications. 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics.
    2-Iodoacetamide (Standard)
  • HY-W004702R
    Methyl methanesulfonate (Standard)
    Methyl methanesulfonate (Standard) is the analytical standard of Methyl methanesulfonate (HY-W004702). This product is intended for research and analytical applications. Methyl methanesulfonate is an alkylating agent which transfers methyl groups, and induces DNA damage. Methyl methanesulfonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Methyl methanesulfonate (Standard)
  • HY-109146
    Imifoplatin
    Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity.
    Imifoplatin
  • HY-117433S
    4-Hydroperoxy Cyclophosphamide-d4
    4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders.
    4-Hydroperoxy Cyclophosphamide-d<sub>4</sub>
  • HY-139059
    ERD03
    		Inhibitor 99.98%
    ERD03 is a potent disruptor of the EXOSC3-RNA interaction, with a Kd of 17±7 μM . ERD03 induces PCH1B-like phenotype in zebrafish embryo and can be used for neurological disorder disease research.
    ERD03
  • HY-16325A
    Miriplatin
    		98.0%
    Miriplatin (SM-11355) is a chemotherapy agent which belongs to the class of alkylating agents.
    Miriplatin
  • HY-13747
    Semustine
    		98.0%
    Semustine is a DNA alkylator, binds to DNA, and acts as a cancer chemotherapeutic agent.
    Semustine
  • HY-D1773
    YOYO-3
    		98.68%
    YOYO-3 is a trimethine cyanine homodimer dye. YOYO-3 intercalates into AF488-tagged dsDNA molecules at the single-molecule level. YOYO-3 has a greater affinity for DNA than do EB and other Cyanine dyes.
    YOYO-3
  • HY-W015205
    5-Bromocytosine
    		99.77%
    5-Bromocytosine is a Cytosine (HY-I0626) derivative. 5-Bromocytosine can be incorporated into cellular DNA and promote DNA chain breakage and cross-linking under ultraviolet irradiation.
    5-Bromocytosine
  • HY-16398
    Pipobroman
    		99.81%
    Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al.
    Pipobroman
  • HY-W111005
    1-Chloromethylpyrene
    		≥98.0%
    1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, resulting in DNA cross-linking, thereby inhibiting the proliferation of tumor cells.
    1-Chloromethylpyrene
  • HY-17420AR
    Cyclophosphamide hydrate (Standard)
    Cyclophosphamide (hydrate) (Standard) is the analytical standard of Cyclophosphamide (hydrate). This product is intended for research and analytical applications. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
    Cyclophosphamide hydrate (Standard)
  • HY-130978
    Duocarmycin DM
    		99.15%
    Duocarmycin DM, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.
    Duocarmycin DM
  • HY-13733A
    Procarbazine
    Procarbazine is an orally active alkylating agent, with anticancer activity. Procarbazine can be used in Hodgkin's disease research.
    Procarbazine
  • HY-129355
    Duocarmycin analog-1
    Duocarmycin analog-1 is an analog of Duocarmycin, and used as an DNA alkylator and ADC cytotoxin.
    Duocarmycin analog-1
  • HY-17420S
    Cyclophosphamide-d4
    		99.46%
    Cyclophosphamide-d4 is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.
    Cyclophosphamide-d<sub>4</sub>
  • HY-17419S1
    Ifosfamide-d4
    		99.85%
    Ifosfamide-d4 is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
    Ifosfamide-d<sub>4</sub>
  • HY-W013741
    CME-carbodiimide
    		98.0%
    CME-carbodiimide is a nucleic acid modification reagent. CME-carbodiimide reacts specifically with uracil and guanine residues of RNA, as well as guanine and thymine residues of denatured DNA; it does not react with native DNA. Modification of DNA by CME-carbodiimide inhibits phosphodiester bond cleavage or DNA hydrolysis mediated by pancreatic ribonuclease, snake venom phosphodiesterase and deoxyribonuclease.
    CME-carbodiimide
  • HY-17393S
    Carboplatin-d4
    		99.0%
    Carboplatin-d4 is the deuterium labeled Carboplatin. Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
    Carboplatin-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity